Optimization of a coronavirus genus recognition procedure based on the n-gene of prototypic strains

The article offers a solution to the problem of fast and efficient recognition coronavirus genus. For this purpose, authors apply virus genome targeting method based on use sufficiently short conserved N-gene nucleocapsid protein. Comparison codon frequency distributions in analyzed set 67 prototypical strains corresponding subgenus allows us recognize genus coronavirus. This paper proposes optimization by eliminating significant number codons from 64 genetic code (26 one case 57 other). achieved 100% efficiency sample 2,051 genomes GenBank database with annotated optimized procedure. also 99% confidence when using procedure total 3,242 genomes.